嗅上皮背側領域特異的にCreリコンビナーゼ (iCre) を発現するノックインマウス。嗅上皮の背側領域にかけて嗅細胞においてCreリコンビナーゼの発現が観察される。任意の遺伝子のfloxedマウスとの交配により嗅神経細胞における特定遺伝子の機能解析に利用できる。 C(3〜6か月) Heterozygote x Wild-type [or Crossing to Crlj:CD1(ICR)] Heterozygote x Wild-type [or Crossing to Crlj:CD1(ICR)] O-MACS-Cre, Acsm4/cre KI O-MACS-Cre, Acsm4/cre KI <a href='https://brc.riken.jp/mus/pcr06346'>Genotyping protocol -PCR-</a> C (3-6 months) true Developed by Yuichiro Oka, Graduate School of Science, The University of Tokyo in 2004. D3 ES cells were used to generate the mutant mice. IICR mixed background. OMACS (Acsm4) cre (iCre) knock-in mice. ICR.Cg-Acsm4<tm1(cre)Hsak> 坂野 仁 ICR.Cg-Acsm4<tm1(cre)Hsak> phage P1 cre recombinase, SV40 polyA signal, yeast FRT (flipase recombination target) sites, mouse phosphoglycerate kinase promoter, E.coli neo, mouse Acsm4 (olfactory specific medium-chain acyl CoA synthetase) genomic DNA RBRC06346 Neurobiology Research In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 450, 503-508 (2007).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. 東京大学大学院理学系研究科・岡 雄一郎先生(2004)。D3 ES細胞を用いて作出。ICR混合背景。 D3 [129S2/SvPas] Hitoshi SAKANO 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Nature, 450, 503-508 (2007).<br>研究成果の公表にあたって謝辞の表明を必要とする。 Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Cre/loxP system